Q4. The total clearance (CL) and hepatic

clearance (CL) of amlodipine are 49 L/h

and 44 L/ h, respectively. Calculate the

renal clearance (CLR) of this drug. What

assumption was made when calculating

CLR? Based on clearance data provided,

what is the main elimination mechanism

for amlodipine? Alaa

Q5.The hepatic extraction ratio of

amlodipine is 0.5. Would you expect

changes in (i) the fraction unbound in

plasma of amlodipine, and (ii) hepatic

blood flow to affect the CL of amlodipine?

Explain your reasoning. How would your

answer be different if the hepatic

extraction ratio was 0.9? Alaa