2. Define parameter half-life.

Calculate clozapine half-life in non-smoker and smoker patient groups using clearance values

calculated in question 1 (see PKPD Table). Assume volume of distribution and corresponding average

body weight (BW) of each of the patient group as listed below:

a) Non-smokers: V= 5.5 L/kg, average BW= 75 kg

b) Smokers: V = 6 L/kg, average BW = 67 kg